Juniper Publishers-Biomedical Engineering Journals

Controlling Informative Features for Improved Accuracy and Faster Predictions in Omentum Cancer Models Authored by Damian R Mingle  Identification of suitable biomarkers for accurate prediction of phenotypic outcomes is a goal for personalized medicine. However, current machine learning approaches are either too complex or perform poorly. Here, a novel feature detection and engineering machine-learning framework is presented to address this need. First, the Rip Curl process is applied which generates a set of 10 additional features. Second, we rank all features including the Rip Curl features from which the top-ranked will most likely contain the most informative features for prediction of the underlying biological classes. The top-ranked features are used in model building. This process creates for more expressive features which are captured in models with an eye towards the model learning from increasing sample amount and the accuracy/time results. The per...

Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway Authored By Kulvinder Kochar Kaur, Ovarian Cancer gets diagnosed in advanced stage in 75% of patient and thus remains one of the most lethal gynecological malignancies. Despite 80% patients being responsive to platinum based chemotherapies to start with most relapse finally. Hence need of the hour is to find more effective immunotherapy’s to be added to these CRT. Programmed cell death1 (PD1) -PDL1 is an important immune pathway which is discussed in detail along with role of nivelumab (a monoclonal antibody against PD1) and addition of other immunotherapy’s like bevacizumab, Olafarib (A PARP (polyadenosine diphosphate (ADP)-ribose- inhibitor), C edinarib (a VEGF123 inhibitor) etc to increase five year survival. Reasons of why success not obtained as expected is further sought through Effect of IFNγ on PDL1 pathway and different NK cellular phenotypes is further analyzed besi...

Neurobehioural Effects of Chronic Consumption of Uncooked Black Eye Beans on Spatial Learning and Memory in Mice Authored by AduemaW Beans, the stable diet of Nigerians contains serotonin and its precursor, 5-Hydroxytryptophan. Serotonin as a neurotransmitter has neurobehavioural actions which include mood, memory, learning and sleep. It was therefore the aim of this study to find out whether long term consumption of uncooked black eye beans (Vigna unguiculata) diet commonly called iron beans, has effects on some neurobehavioural parameters notably; learning and memory, using Swiss white mice as experimental animals. Thirty (30) CD1 mice weighing 18-30g were randomly assigned into three groups, viz; control, uncooked beans and serotonin precursor. They were fed normal rodent chow and 50% uncooked beans diet (w/w), while another set of mice were placed on serotonin precursor (5-HTP) diet (0.2mg/50g w/w) respectively for four weeks. All the mice had access to clean drinki...

A Retrospective Analysis of Ibrutinib-Associated Pneumonia Authored by Rohan Ramnarain Tyrosine kinase inhibitors and their modulation of cancer cell proliferation may be associated with various adverse events serious enough to consider a change in therapy. Specifically, pneumonia rates among patients with cancer have been rising steadily for the last decade, perhaps due to increased use of stronger, sometimes immune modulating drugs such as ibrutinib. This particular agent targets Bruton’s tyrosine kinase, which is expressed most prominently in B cells, the cell from which most non-Hodgkin’s lymphomas and chronic lymphocytic leukemia originate. The FDA has a publically available database that contains all adverse event reports from consumers, medwatch, and drug companies. This database is known as the FDA Adverse Event Reporting System (FAERS) and it contains over 10 million reports of adverse events that have been de-identified for safety of the patients reporting t...

Remote Monitoring To Achieve Self-Management of Type 2 Diabetes Mellitus: A Prospective Study Authored by Hayat Mushcab The prevalence of type-2 diabetes mellitus (T2DM) is increasing rapidly worldwide [1]. In 2000, the prevalence of T2DM was estimated to be 2.8 percent of the world’s population, which meant that 171 million people were living with diabetes mellitus around the world and it was projected that the number would increase to 366 million by 2030 (WHO 2016) [2]. However, in 2014, the World Health Organization estimated the prevalence of T2DM amongst adults to be 9 percent of the world’s population that is equivalent to 450 million people living with diabetes in addition to 179 million people living with undiagnosed diabetes [3]. Life expectancy around the world has increased due to the continued advances in science and technology [4]. Consequently, the world’s population is aging, and more people are living with chronic conditions including diabetes mellit...

Physiological Complications are Related with Gestational time Associated Maternal Ages- a Survey Based Research Authored by Debendra Nath Roy A woman’s ability to adapt to the changes and challenges of pregnancy is unique and the level of the stress she experiences affects the outcome of pregnancy. Long term complication in pregnancy is an important health problem as it often occurs in the context of poor social support and maternal wellbeing. Complications and risks associated with pregnancy among women have been addressed in numerous studies from different viewpoints; mostly focusing on the medical risks associated with higher maternal age. Present study was carried out to expand the knowledge base regarding the potential physiological and psychological complications faced by women during the stage of pregnancy at different wedding ages. Our current showed that, although above 60% were observed no preexisting history, but around 60% complications started for those ...

CMV Seroconversion Associated with an high Avidity in a Previously Seronegative Pregnant Woman during her first Trimester of Pregnancy Authored by Quentin Delefortrie Recently, we observed in our laboratory a CMV seroconversion with the appearance of CMV-specific IgGtogether with an IgM response in a previously seronegative pregnant woman during her first trimester (week 14) of pregnancy (kit used: Liaison® CMV IgGII and IgMII kits,Diasorin®, Italy). Surprisingly, the latest sample displayed high avidity using the Liaison® IgG Avidity II kit (Diasorin®, Italy). Similar results were observed with those samples using the Vidas® CMV IgG, IgM and Avidity kits (biomérieux®, France) To Read More.. PHP in Juniper Publishers in Current Trends in Biomedical Engineering & Biosciences