Juniper Publishers: New Insight into the Treatment of Primary Myelofib...

Juniper Publishers: New Insight into the Treatment of Primary Myelofib...: Cancer Therapy & OncologyInternational Journal   Juniper Publishers Abstract PMF belongs to the category of myeloprolife...

Comments

Post a Comment

Popular posts from this blog

How Juniper Publishers Ensures High Editorial Standards

How Juniper Publishers Ensures High Editorial Standards Introduction Maintaining high editorial standards is critical in academic publishing to safeguard research quality and integrity. Juniper Publishers, an open-access publisher, outlines several mechanisms it employs to uphold these standards across its wide range of scientific journals. 1. Rigorous Peer Review System At the core of Juniper Publishers’ editorial process is a double-blind peer review system. This means both the reviewers and authors remain anonymous, reducing bias and promoting objective assessment. Manuscripts undergo evaluation for: Scientific validity Originality and relevance Logical structure and coherence Adherence to the journal’s scope This helps eliminate substandard or non-original work before publication. 2. Qualified Editorial Board Members Juniper relies on an international editorial board consisting of domain experts, researchers, and academicians. Their responsibilities...
Read more

Application of (bio) chemical engineering principles and lumping analysis in modelling the living systems

  Abstract The ”whole-cell” simulation of cell metabolic processes under considering a variable-volume modelling framework has been reviewed to prove their advantages when building-up modular model structures of simplified form that can reproduce complex protein syntheses inside cells. The more realistic “whole-cell-variable-volume” (VVWC) approach is reviewed when developing modular kinetic representations of the homeostatic gene expression regulatory modules (GERM) that control the protein synthesis and homeostasis of metabolic processes. The paper review the general concepts of the VVWC modelling, while the cited literature includes past and current experience with GERM linking rules in order to point-out how optimized globally efficient kinetic models for the genetic regulatory circuits (GRC) can be obtained to reproduce experimental observations. Based on quantitative regulatory indices evaluated vs. simulated dynamic and stationary environmental perturbations, the reviewed li...
Read more

Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway

Image
Advances in the Therapy of Advanced Ovarian Cancer-Special Emphasis on the PD1/PDL1 Pathway Authored By Kulvinder Kochar Kaur, Ovarian Cancer gets diagnosed in advanced stage in 75% of patient and thus remains one of the most lethal gynecological malignancies. Despite 80% patients being responsive to platinum based chemotherapies to start with most relapse finally. Hence need of the hour is to find more effective immunotherapy’s to be added to these CRT. Programmed cell death1 (PD1) -PDL1 is an important immune pathway which is discussed in detail along with role of nivelumab (a monoclonal antibody against PD1) and addition of other immunotherapy’s like bevacizumab, Olafarib (A PARP (polyadenosine diphosphate (ADP)-ribose- inhibitor), C edinarib (a VEGF123 inhibitor) etc to increase five year survival. Reasons of why success not obtained as expected is further sought through Effect of IFNγ on PDL1 pathway and different NK cellular phenotypes is further analyzed besi...
Read more